The new store - set to open in the second half of 2020 - will house over 200 beauty brands, including NARS, Morphe, Drunk Elephant, Tatcha and Diptyque.
In addition to the extensive selection of products, there will be hair and body treatment areas, a Beauty Lab for makeup artistry, a Perfumeria, pop-ups and space for events and entertainment.
Makeup, Skincare and Fragrance specialists will also be on-hand to help shoppers pick out the best-suited products and learn new techniques.
Mecca will move into the space currently occupied by British fashion label Topshop and will make this new shopfront the brand's flagship store.
Mecca Founder and Co-CEO Jo Horgan said: "I’m thrilled to be creating a store that embodies our exciting vision for the future of beauty and restores Gowings to its former glory with an experience-led strategy that puts the joy back into shopping. It will be the ‘beating heart of beauty’ in the Sydney CBD”.
Jane Hastings, CEO Event Hospitality and Entertainment at Mecca, also commented on the news, saying: “We are excited to welcome the Mecca flagship store as part of our strategy to further strengthen the QT Hotel and State Theatre precinct.
"Gowings is one of Australia’s busiest pedestrian corners, incorporating the elegant State Theatre, award winning QT Sydney Hotel and highly regarded dining establishments Gowings Bar and Grill and the latest Parlour Cucina.
"Mecca is a perfect fit to compliment a corner where hospitality, entertainment and beauty set a world class standard of their own”.
By the time it opens, Mecca at Gowings is expected to be the business’s 115th store across Australia and New Zealand.