Selena Gomez, a long friend of Aniston's, added: "NO ONE TALK TO ME. I'M NOT OK."
It just so happens that Gwyneth Paltrow is also a firm fan of the US sitcom (and caps lock).
"NO F'IN WAYYYYY," the Goop founder commented.
Over on Cox's Instagram post, celebrity reactions are also in full swing.
Most notably, Reese Witherspoon, who famously played Rachel Green's sister Jill Green in the year 2000, commented.
"WHAT????!!! THIS IS THE GREATEST NEWS EVER!!" she wrote.
Meanwhile, Ashley Benson quoted Janice with a simple-but-effective: "OH MY GOD".
The news comes 15 years after the small screen's most beloved friends left our screens for good (bar our hungover rerun-after-rerun weekend sessions, of course).
According to the Hollywood Reporter, the famous cast will appear alongside show creators, David Crane and Marta Kauffman, for an unscripted special with HBO Max.
The highly-anticipated episode, set to be filmed at the Warner Bros. Studio lot in California (where the show was originally shot) will mark the first time all six members have been at a public event together since 2004.
Apologies in advance but, could we BE any more excited?