Schumer and her husband Chris Fischer welcomed their first child, a son named Gene Attell, in May 2019.
During the pregnancy, she kept things real with fans and posted candid photographs of everything from her stretch marks to the realities of hyperemesis gravidarum, a condition which causes severe nausea and vomiting.
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Chrissy Teigen and husband John Legend welcomed their first child, Luna Simone Stephens, in April 2016 before their son Miles Stephens was born in May 2018.
But the A-list couple's journey to parenthood was a difficult one.
The model has always been open about the couple's infertility struggles and wasn't afraid to call out people who criticised their decision to choose the sex of their first born child.
"From reading everything tonight, I think I made a mistake in thinking people understood the process better than they do, which is my fault," Teigen tweeted.
"We didn't create a little girl. We had multiple embryos. Girls and boys. We simply chose to put in a female first (and second)..."
Courteney Cox suffered several miscarriages before learning that she has a rare antibody in her blood which prevents pregnancies from reaching full term.
The actress underwent IVF twice before going on to welcome her first child, Coco Arquette, with former husband David Arquette in June 2014.
But it was difficult for the star to cope with the loss and Cox recently revealed that the difficult period of life coincided with the last year of filming Friends.
Céline Dion welcomed her first child, Rene-Charles, with husband Rene Angelil in January, 2001 after several rounds of IVF.
In the years that followed, the couple continued to try to give their son a sibling.
After six further IVF treatments, the songstress gave birth to twin boys, Eddy and Nelson, in 2010.
Speaking about trying to fall pregnant in her 40s, Dion told Good Morning America: "It's priceless. So, you know what? We had a miscarriage. We tried [IVF] three more times. It did not work... We are trying again for the fifth try. It's aboard right now. All aboard."
In her 2018 memoir Becoming, the former First Lady revealed that her and husband Barack Obama welcomed their daughters, Sasha and Malia, via IVF.
At around 34-years-old, Michelle Obama grew aware that the "biological clock is real" which inspired her decision to undergo treatment.
"I think it's the worst thing that we do to each other as women, not share the truth about our bodies and how they work," Obama said during an appearance on Good Morning America.
The process was difficult for the former presidential couple with Michelle having to administer IVF shots on her own while Barack worked.
Eventually, the couple sought therapy to help them support each through the process.
"I know too many young couples who struggle and think that somehow there's something wrong with them," she told Good Morning America.
"And I want them to know that Michelle and Barack Obama, who have a phenomenal marriage and who love each other, we work on our marriage. And we get help with our marriage when we need it."