That Flower Films, her production company, has made more than $1 billion at the box office (thanks to movies such as How to Be Single, Donnie Darko, Charlie's Angels and 50 First Dates). Her make-up and eyewear line Flower is launching an e-commerce site his year and may expand overseas, including Australia, and that sommeliers across the US have added Barrymore Wines to their lists. Then there's her memoir, Wildflower, released last year, which cemented her position as an accomplished writer.
Here, a few highlights from her interview, in our July issue, on sale June 9:
On fame and celebrity friendship: "I've never felt comfortable with this, sort of, camaraderie of famous people. I've known Poo Poo [Cameron Diaz] since I was 14 years old. We just happened to know each other before her career started, and I was working in a coffeehouse trying to refigure out my life. So in a weird way, it doesn't even count with us."
On making an effort: "I went to parent's night, and I wore some lipstick and concealer, and I thought the people at school looked at me kind of differently. I normally come with acne, and Ugg boots, and I thought they were like, 'Oh that's nice, she made a little bit of an effort.'"
On trying to do it all: "I really had to tell myself, You can do everything, but you will have to do them at different moments. And you can do a lot in the same moment, but you can't do everything in the same moment. It was a good lesson that you will just have to prioritise and put some things over here for a little while."