Brother Richmond confirmed the sad news via Facebook, writing:
“Our brother Robert, who became our brother Alexis, who became our sister Alexis, passed this morning September 11, at 12:23am,” he wrote.
“He was surrounded by all of his brothers and sisters, one of his nieces and several other loves ones. We were playing music for him and he passed during David Bowie’s ‘Starman.’
"As per his wishes, we cheered at the moment that he transitioned to another dimension.”
No official cause of death has been revealed however several news sources are reporting that Arquette had been battling an illness.
Arquette, who was born a male, transitioned to female in 2006, which was the subject of a documentary titled Alexis Arquette: She’s My Brother.