“Their mother died a week after she delivered the babies” in August 2012, Mvula tells People.
“After their mother died, the children were looked after by their grandmother, who could not fully provide for them, so they were taken into an orphanage.”
A government-appointed official will now reportedly travel with the singer to the US where she must prove she can provide a suitable home and to observe how she looks after them.
Madonna has previously adopted two children from Malawi, David Banda in 2006 and Mercy James in 2009 and is also mother to two biological children, Lourdes Leon, 20, and Rocco Ritchie, 16.
The singer initially dismissed reports she was intending to adopt more children when she visited the country back in January and has yet to comment.