Christina Lynn Brajcic experienced severe pain immediately after having the mesh implanted in 2013 following the birth of her second son, Sydney Morning Herald reports.
Her surgeon dismissed the complications as side-effects of the mesh "settling in" to her body, but the pain only worsened with time.
Christina eventually had the mesh removed, but spent much of the past four years confined to a wheelchair and on constant antibiotics and painkillers.
"How did I go from having an infection to heart failure? At 42? Dang mesh," the mesh campaigner said in a Facebook live video from her hospital bed only weeks ago.
"I don't want this to happen to anybody. This is insane," she continued.
"To... almost be on your death bed at 42 because of mesh, it's not right. I'm terrified at what we all go through and I never want another woman or man dealing with mesh to go through this."
Christina's died in hospital on Thursday after emergency treatment in late October for sepsis, a life-threatening response to infection that can lead to organ failure. Her death has prompted outcry from women all over the world who are suffering from mesh implants.
Just last week, pelvic mesh implants were banned from Australia.