Madeleine's case was initially closed in 2008, but after more reviews of the documents, the case was reopened in 2013.
The desparate faces and pleas from Madeleine's parents, Kate and Gerry McCann, have been front and centre of the media frenzy, and last year, the parents celebrated what would have been Madeleine's 18th birthday with another call for help.
"We hang on to the hope, however small, that we will see Madeleine again," they said in May 2021.
"As we have said repeatedly, we need to know what has happened to our lovely daughter, no matter what. We are very grateful to the police for their continued efforts.
"We still receive so many positive words and good wishes despite the years that have gone by. It all helps and for that, we are truly grateful – thank you."
More to come.